Abstract

Type 2 Diabetes Mellitus and Subclinical Hypothyroidism Coincidence and Its Effect on Triglyceride Glucose Index (TyG) and Atherogenic Index of Plasma (AIP)

Objective: Type 2 Diabetes Mellitus and subclinical hypothyroidism have been common diseases in the adult general population. There has been an increased recognition that more attention needs to be paid to this area since two diseases affect each other according to studies. Moreover, there has been lacking data in guidelines and study results on SCH and diabetes complications. Triglyceride indexes and thermogenic indexes have been valuable to demonstrate diabetes control levels and complications risk. Therefore we aimed to investigate the effect of SCH on these indexes in patients with type 2 Diabetes Mellitus. Methods: 315 (after exclusion criteria 299) type 2 diabetes patients and 92 healthy controls, matched for age and sex were enrolled in the study. Patients were divided into two groups according to SCH co-occurrence. Waist circumference, Plasma glucose, lipid profile, and Urinary Albumin-Creatinine Ratio (UACR) was compared between groups. TyG, TyG-Body Mass Index, TyG-Waist Circumference, and AIP were calculated to compare the two groups. Results: SCH frequency was 14.1% (13/92) in healthy subjects and 10.6% (32/298) in type 2 diabetes patients (p=0.377). TG levels were higher in T2DM patients with SCH (208.0 ± 91.4 vs 169.83 ± 78.4 mg/ dl, p=0.03) UACR was found significantly higher in T2DM patients with SCH (p<0.05). WC, FPG, and HbA1c were not found associated with TSH levels (p=0.41, p=0.42, p=0.22, accordingly) Urine Albumin Creatinine Ratio was found associated with Thyroid Stimulating Hormone (p=0.03). TyG-Body Mass Index, TyG-Waist Circumference and Adaptive Internet Protocol were found to increase in the SCH group (p<0.01 in three groups). Conclusions: According to current results, SCH was found not infrequently in patients with T2DM, additionally hypertriglyceridemia and microalbuminuria tend to be higher in patients with diabetes mellitus and coexisting SCH. As well as TyG-Body Mass Index, TyG-Waist Circumference and Adaptive Internet Protocol were found to increase in the SCH group. TyG index was shown to be associated with poorer glucose control Therefore the overlap of these two clinical situations could facilitate life threatening comorbidities.

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