Abstract

The healing effect of combined hydroalcoholic extract of Teocurium polium and the seed hull of Quercus brantii on burn wounds in rats

Author(s):Mohammadi Jamshid, Nikbakht Jafar, Mohammadi Bahram, Jafari Barmak Mehrzad, Vafaienejad Tahereh and Talebianpoor Mohammad Sharif

Plants and their extracts have considerable potential for wound healing. So, The aim of this study was to evaluate the wound healing effect of combined hydroalcoholic extract of Teocurium Polium (TP) and the seed hull of Quercus brantii (Persian oak) (QB) and comparing with silver sulfadiazine (SSD) ointment (1%) in rats. Animals were divided into six groups consist of normal (untreated), physiologic serum, TP, seed hulls of Quercus brantii (QB), combination of TP and QB and the other group was SSD. Burn area size, epidermal and dermal diameter, number of hair follicle, histopathology of the burn skin and concentration of plasma malondialdehide (MDA) were determined in different groups. Animals treated with QB and TP, SSD and combination of two extracts (QB +TP) showed a significant reduction in the burn area. Serum MDA decreased significantly in animals treated with QB, TP and QB+TP. Histological comparison has shown that TP, QB and combination of them significantly increased reepithelialization in burn wounds, as compared to normal group. In conclusion, our results demonstrated that topical application of TP and QB has a significant effect on the burn wound healing.

• PDF