Abstract

The comparison of endurance training with moderate intensity and overtraining on Th1/Th2 balance in wistar male rats

Immune system has role in inflammatory and anti inflammatory function. Base of these activities is produce IL4 and IFNγ. This study is about effects of endurance training with moderate intensity and overtraining on balance these two cytokines. In this study 30 rats selected and divided to 3 groups control, moderate and overtraining exercise. Moderate training protocol was done for 12 weeks with speed 30 m/min in first week and 23m/min in last week. Overtraining protocol was done with speed 15 m/min in first week and 25 m/min in last week. All protocol of training was for 12 weeks. Speleenectomy where done after interval training protocol, and Eliza method used to, Interleukin 4 (IL4) and Interferon γ (IFNγ).The results of this study showed a increase in the amount of (IFNγ) and decrease in the levels of IL4 in moderate training group that difference was significant (p=0.01). The results also showed increase in levels of IL4 and decrease IFNγ levels in overtraining group difference was significant (p=0.01).Based on the results of this research, it can be concluded that doing moderate training lead to increase IFNγ and overtraining case to increase IL4

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