Abstract

Study of Serum Copeptin Levels in Newly Diagnosed Hypothyroid Subjects

Introduction: Hypothyroidism is one of the most commonly occurring thyroid disorders worldwide. Hypothyroidism is due to decreased circulating levels of thyroid hormones and is caused by inadequate functioning of the thyroid gland. Copeptin (CPP), the C-terminal part of the vasopressin prohormone, is released stoichiometrically with arginine-vasopressin from the neurohypophysis and seems to reflect the individual endogenous stress level and also the mortality risk in coronary events. This study aimed to determine Copeptin levels in hypothyroidism and to evaluate the relationship between CPP and thyroid hormone levels. Methodology: The present study was conducted on 80 newly diagnosed hypothyroid subjects attending the Medical OPD and Immunoassay Laboratory of the Department of Biochemistry, S.P. Medical College and Hospitals, Bikaner. The results of patients were compared with 80 healthy controls of either sex of a similar age group (20-65 years). The blood samples were collected from all the subjects and analyzed for serum thyroid profile and CPP. The thyroid profile was estimated by the electro-chemiluminescence system, using an automated Beckman coulter immunoassay analyzer. Cpp was estimated by Elisa kit using Merilyzer. Results: The mean serum CPP level was observed statistically highly significant (p<0.001) in hypothyroid subjects (192.71 ± 58.68 pg/ml) as compared with healthy control subjects (51.28 ± 11.37 pg/ml). A highly significant positive correlation was found (+0.89) between CPP with TSH (p< 0.001) and significant negative correlations were found between CPP with T3 and T4 in hypothyroid subjects. Conclusion: CPP levels in hypothyroid subjects might be useful as an early marker to detect future cardiac and endothelial diseases

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