Abstract

Study of Correlation between hs-CRP and Lipid Profile in Vitamin D Supplemented Hypothyroid Patients

Background: Hypothyroidism is a common ailment affecting people globally due to deficiency of thyroid hormones along with their slow metabolism. It is associated with dyslipidemia and inflammation. The hs-CRP (high sensitivity- C-Reactive Protein) is a significant inflammatory marker. A vitamin D deficiency is witnessed in autoimmune diseases and metabolic syndromes. Low vitamin D levels, inflammation, and dyslipidemia were proved to have a connection with autoimmune thyroid diseases. Objectives: Our study aims to estimate the relationship between hs-CRP and lipid profile in vitamin D supplemented hypothyroid patients in comparison to controls and also to compare the abovementioned parameters in without vitamin D supplemented hypothyroid cases. Methods: A cross-sectional study of 6 months period was conducted among 90 subjects attending the General Medicine department of Shadan Institute of Medical Sciences. Based on the inclusion and exclusion criteria, 90 subjects were divided into 3 groups, G-1 (controls=30), G-2 (Vitamin D supplemented hypothyroid subjects=30), and G-3 (without vitamin D supplemented hypothyroid subjects=30). Healthy age and gender-matched euthyroid subjects were taken as controls and patients who were newly diagnosed as hypothyroid, (with increased serum TSH and or with decreased serum T3 or serum T4 levels) were taken as cases. Levels of serum vitamin D, hs-CRP, indicators of thyroid profile (serum TSH, T3, and T4), and indicators of lipid profiles (TC, TAG, HDL, and LDL) were compared between groups. Anthropometric measurements for body mass index were also calculated. Results: 90 subjects participated in our study, the subjects were agematched and female predominance was observed. BMI calculations showed no significant change between the study groups. The hs-CRP levels were improved and found to be statistically significant, in vitamin D supplemented hypothyroid patients. Serum TSH, T3, and T4 levels were within the optimal range. Serum TC mean values were decreased in vitamin D supplemented hypothyroid patients. There was not much difference in HDL levels but an increase in triglycerides and LDL levels with a statistical significance was noted in the vitamin D supplemented hypothyroid patients. When vitamin D supplemented hypothyroid patients and without vitamin D supplemented hypothyroid patients were compared, the TC, TAG, and LDL mean values were decreased and HDL mean value was increased. Between serum TSH and hs-CRP levels of vitamin D supplemented hypothyroid patients, a positive correlation was found, along with statistical significance, when tested by ANOVA. Conclusion: Hypothyroidism is found to be prevalent in females and is associated with mild dyslipidemia. When vitamin D supplemented hypothyroid subjects and without vitamin D supplemented hypothyroid subjects were compared, there was a significant control in hs-CRP levels supporting the advisability of vitamin D supplementation for hypothyroid patients.

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