Abstract

Several molecular factors/genes that are involved in making development of resistance against Plasmodium falciparum induced disease progression in human species

Malaria is an acute parasite-induced disorder caused because of infection induced by a species of plasmodium parasites. The life cycle of Plasmodium parasites occurs through 3 stages: Gametocytes, Sporozoites, and Merozoites. The onset of clinical symptoms happens within 7 days to 10 days of the initial mosquito bite have dormant forms called the hypnozoite stage. Malaria caused by Plasmodium falciparum can be of 4 types: - asymptomatic, symptomatic, severe, or placental. Some factors like hemoglobinopathy (sickle cell anemia, thalassemia, etc.), low oxygen saturation, Glucose-6-phosphate dehydrogenase deficiency, and dantu mutation in glycophorin molecules provide natural resistance against malaria. Generally, most of antimalarial drugs (chloroquine, primaquine, etc.) work based on these molecular factors, responsible for providing resistance against malaria.

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