Abstract

SERUM LEVELS OF HIGH SENSITIVITY C REACTIVE PROTEIN AND MALONDIALDEHYDE IN CHRONIC KIDNEY DISEASE

Background: Chronic kidney disease cases are at increased risk for progression to end stage renal disease and accelerated atherosclerosis, with premature cardiovascular morbidity and mortality being the more frequent outcome. Aim: The study was taken up to find if there is any association between nontraditional cardiovascular risk markers like high sensitivity C reactive protein (marker of inflammation) and malondialdehyde (marker of lipid peroxidation) with the progression of chronic kidney disease. Methodology: The study included 44 pre dialysis chronic kidney disease cases and 44 healthy controls. Serum levels of creatinine, high sensitivity C reactive protein and malondialdehyde were estimated in both groups. The mean estimated glomerular filtration rate(eGFR) in chronic kidney disease patients was calculated by the MDRD formula. Results: The mean eGFR in cases was found to be 23.65 14.99 ml/min by MDRD formula. The serum hsCRP and malondialdehyde levels in cases was 11.8 7.24 mg/L and 3.02 1.24 nmol/ml respectively. Conclusion: There was a significant negative correlation (p<0.001) between high sensitivity C-reactive protein and malondialdehyde with eGFR. A highly significant positive correlation was found between serum hsCRP and malondialdehyde (p<0.001) in chronic kidney disease underlining the synergism between oxidative stress and inflammation, perpetuating to further deterioration of renal function and enhancing the predisposition to cardiovascular risk with the progression of chronic kidney disease.

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