Abstract

Rolapitant: Effects of an Antiemetic Agent on the Growth of Developing Chick Embryo

Aim: The purpose of this study was to determine the effect of Rolapitant, an antiemetic agent, on chick embryo development in 200 white leghorn chicken eggs used that met the inclusion-exclusion criteria.

Material and method: The present study utilized 200 eggs, randomly assigned to experimental groups A and B and control groups a and b. Eggs incubated in the presence of Rolapitant had their Rolapitant dose increased on the fifth day of incubation from 0.18 mg to 0.36 mg. In contrast to the control groups, all of the subjects in the treatment groups received the same amount of normal saline. Eggs were broken on the twentieth day of incubation, and embryos were extracted on the same day.

Results: The weight and CRL of the chick embryos were measured, and gross anatomical malformations were observed-the percentile lethality of Rolapitant increase with dose with the odds ratio of 1.175 and 1.313. While analyzing the abnormal weight and abnormal CR length due to the effects of Rolapitant, a significant difference was observed. In each case, an increased t-value concerning an increase in dose shows the lethality of Rolapitant.

Conclusion: The present study observed an increased mortality rate and a decrease in weight and crown-rump length following a double dose of Rolapitant. The author remanded additional research with a larger sample size to improve the current observation’s reliability and generalizability.

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