Abstract

Ki-67 Immunostaining in Epithelial Ovarian Tumors with Clinicopathological Correlation

Background and Objective: Ovarian cancer is the 8th most common gynecological cancer causing over 15,000 deaths globally. Surface Epithelial Ovarian Cancer (SEOC) comprises different ovarian tumors differing in histopathology and prognosis. Since Ki-67 is economical and reliable, hence it can be employed for assessing tumor behavior, its progression, prognosis, and evaluation of therapeutic response. This study aimed to study the Ki-67 expression in benign, borderline, and malignant SEOC along with its correlation with clinicopathological parameters. Methods: The prospective study included 55 patients having benign, borderline, and malignant tumors who came for routine histopathological evaluation. Tumor histopathology and Ki-67 expression were studied using immunohistochemistry and correlated with the relevant findings. Statistical analysis has been performed with the help of R i386 3.6.3. Continuous variables were given in mean ± standard deviation. Co-relation between the groups was done by Spearman correlation. p-value less ≤ 0.05 indicated significance. Results: Mean age of study subjects observed was 45.11 ± 13.73 (in years) with benign (36.36%), borderline (27.27%), and malignant tumors (36.36%). Serous tumors expressing high Ki-67 indicated increased frequencies of malignant tumors (64.55%). The study depicted a statistically significant correlation between Cancer Antigen 125 (CA125) levels, gross appearance, necrosis, hemorrhage, papillary projections capsular breach, malignant cytology, microscopic findings, tumor stage, and Ki-67 expression (p<0.005). Conclusion: The study infers that Ki-67 expression can be an aiding tool in the clinicopathological diagnosis of SEOC pointing toward the aggressiveness and proliferative nature of the cancerous cells.

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