Abstract

Isolation and identification of pharmacologically active compounds in fruit of Pyrus pashia

The aim of this work is to investigate pharmacological active compounds analysis and their anti-inflammatory activity of Pyrus pashia fruit. In this work some pharmacological active compounds were isolated by column chromatographic techniques and identification of their structure by spectroscopic (NMR, IR, Mass, UV, etc.) methods. Lupeol, β-Sitosterol and β-Sitosterol –ß-D glucoside compounds were isolated. These compounds firstly were isolated from Pyrus pashia fruit. The anti-inflammatory activity of these compounds has been investigated with in vivo study. In this study, it has been shown that Pyrus pashia isolated compounds showed potent antiinflammatory activity. The active ingredient in the extract that reduces the inflammation is not known at present. There is ongoing research to isolate and characterize the bioactive compound (s) responsible for the antiinflammatory activity of Pyrus pashia.

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