Abstract

Histopathological study of lesions of nose and paranasal sinuses and association of Human Papilloma Virus (HPV) with sinonasal papillomas and squamous cell carcinoma

Author(s):Beigh Ambreen*, Tasleem A Reyaz, Junaid Sheikh, Hussain Imtiyaz, Farooq Summyia and Reshi Ruby

A variety of non-neoplastic and neoplastic conditions involve the nasal cavity and paranasal sinuses which are commonly encountered in clinical practice. The nose and paranasal sinuses are exposed to a variety of infections, chemically irritating, antigenically stimulating, traumatic and undoubtedly many other influences and consequences of these multifaceted deleterious exposures result in the formation of tumour-like and truly neoplastic conditions. To study histopathological pattern of sinonasal lesions and association of Human Papilloma Virus (HPV) with sinonasal papillomas and squamous cell carcinomas. The present study was a hospital based observational study conducted over a period of three years from January, 2010 to January, 2013 in the Department of Pathology, Government Medical College, Srinagar which included 181 cases of non-neoplastic and neoplastic lesions of nasal cavity and paranasal sinuses followed by study of association of HPV with sinonasal papillomas and squamous cell carcinomas by polymerase chain reaction (PCR). Out of total 181 cases, 114 were non-neoplastic and 67 were neoplastic. Out of 67 neoplastic lesions, 46 were benign and 21 were malignant. Nasal polyp was most common among non neoplastic lesions. Inverted sinonasal papilloma was most common benign lesion and squamous cell carcinoma was most common malignant lesion seen. Out of a total of 181 sinonasal lesions 101 (55.8%) were present in males and 80 (44.2%) were present in females with male to female ratio being 1.26:1. The age range of patients with sinonasal lesions varied from 5-75 years with a mean age being 34.67 (SD±16.58) years. HPV positivity was seen in 4 (13.33%) out of 30 cases of inverted papillomas, 3 out of 6 (50%) exophytic papillomas tested positive for HPV. Out of 9 squamous cell carcinomas HPV positivity was seen in 2 (22.2%) cases. Categorizing the sinonasal lesions according to histopathological features into various types helps us to know the clinical presentation, clinical outcome and prognosis of the disease. Also low risk HPV types 6 and 11 show an association with sinonasal papillomas and oncogenic HPV types 16 and 18 with squamous cell carcinomas.

• PDF