Abstract

EFFECT OF ANTIOXIDANTS IN PRE ECLAMPSIA WOMEN AT INCREASED RISK.

Preeclampsia is a leading cause of maternal and neonatal mortality and morbidity. It is a complex syndrome of undetermined etiologic origin, usually diagnosed during second half of pregnancy. Elevated levels of oxidative lipid derivatives and reduced antioxidants in the circulation of preeclamptics may contribute to endothelial damage. There is good evidence for a significant increase in the levels of malondialdehyde in plasma and erythrocytes. Group I: Normotensive nonpregnant women (control), Group II: Pregnant women with normal blood pressure, Group III: Preeclamptic (pretreatment), women Preeclamptic women were subdivided into Group IIIA: Pre eclamptic women supplemented with Vitamin E (n=20), Group IIIB: Preeclamptic women supplemented with Omega 3 Fatty Acid, Group IIIC: Preeclamptic women supplemented with Vitamin E 400mg + Omega 3 Fatty Acid. Serum SOD, MDA, GPx, GSH levels were measured in all groups and compared with pre treatment and post treatments results by using the one way ANOVA followed by the Tukey – HSD procedure. Our results showed that supplementation of Vitamin E, Omega 3 fatty acid alone and in combination has significantly increased antioxidant enzyme status and significantly decreased oxidative stress when compared to unsupplemented patients(P< 0.001).

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