In this study we investigated the distribution of brain plaques in patients with clinically definite Multiple Sclerosis diagnosis in Kerman city. So 126 patients with clinically definite Multiple Sclerosis diagnosis in Kerman city were enrolled in the study. The patients were those registered at the Iran Multiple Sclerosis Society, Kerman branch and the diagnosis was based on McDonald revised Criteria. All the patients subjected to T2W and FLAIR Brain MRI. The most common anatomic location of MS plaques was centrum semiovale and juxtacortical and subcortical white matter except the periventricular area (53.96%) and the rarest location was cerebellum (1.89%).No relationship was observed between the anatomical distribution of Multiple Sclerosis plaques and age and duration of disease but there was a relationship between sex and distribution of MS plaques in Brain MRI except the cerebellum and the pons. (p<0.05)
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