Abstract

Development Of Phenytoin Preparation Using Liquid Solid Compact Technology.

Epilepsy is a very common disease, characterized by unconsciousness, which takes a variety of forms and causes episodic neuronal discharge, a type of fainting depending on the part of the brain affected. There is no cause of recognition, although it may develop after a mental injury, such as trauma, infection or trauma, or other neurological diseases. Epilepsy is most commonly treated with drugs, although brain surgery may be used in extreme cases. Sodium channel blockers are commonly used to treat seizures, EG-. Phenytoin, carbamazepine, sodium valproate. This study aimed to develop a matrix tablet for the continuous release of phenytoin using, polyethylene glycol 400, methylcellulose pH 200, sodium alginate, propylene glycol, span 80, tween 80, lactose anhydrous, sodium starch glycolate, magnesium stearate and talc powder as the regulatory factor release. And exploring drug release parameters as various kinetic models. The built-in pills were also available characterized by physical and chemical parameters and results were obtained within acceptable limits. A different finish model used in drug release data to evaluate release modes and kinetics. Terms of choice the most appropriate model was based on line (coefficient of correlation). Based on the value of “n” (0.168) tree the release followed the Ficki distribution. And the drug release method is best described by Higuchi's order (composite value is 0.9063) using this polymer.

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