Abstract

Determination of the Association between Uric Acid Level and Intensity of Coronary Artery Diseases

Some evidences prove that uric acid level is not a risk factor for heart diseases, but oppositely, some communitybased studies point to uric acid as a risk factor of occurrence of cardiovascular diseases. This study evaluates the correlation between these two issues in Iran, which has a high prevalence. In this cross-sectional study, 300 patients who were candidates of CAD were studied. The blood was taken from the patients to do routine tests such as FBS and lipid profile. The blood uric acid level was determined. Angiography of coronary blood was performed after 12 hours of fast. The total serum level of uric acid of all the patients was 5.15±1.47 mg/dl which for men it was 5.27±1.48 mg/dl and it was significantly higher than the same parameter for women (4.88±1.43 mg/dl) (PValue= 0.035). The correlation between the serum uric acid level and the LVEF did not show any significant relationship (P-Value= 0.161). Smoking, hypertension, diabetes, or hyperlipidemia did not influence the blood uric acid level. There was no significant relationship between the serum uric acid level and the number of involved coronary blood artery; however, the serum uric acid level in the patients with the left main involvement was significantly higher than patients without it (P-Value=0.018). In the multivariable logistic regression statistical model, the serum uric acid level is considered as an index in prediction of left main involvement beside other to-bestudied parameters such as sex, age, cardiac risk factors, LVEF level, and serum creatinine level. Increased levels of uric acid is related to the risk factor of left main occurrence dependably from other heart health risk factors such as hyperlipidemia, hypertension, and diabetes. But probably increased level of uric acid has no relationship with involved coronary blood artery.

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