Abstract

Correlation between diabetes autoantibodies and environmental parameters in type 1 diabetics and their siblings in Abidjan District, Ivory Coast

Objective: The aim of this work is to determine the correlation between the presence of diabetes autoantibodies and certain environmental parameters and diet in type 1 diabetes (T1D) and their siblings.
Methods: The study population consisted of 49 people, including 19 with T1D and 30 siblings of first degree whose blood and faeces were collected. T1D were recruited from two University hospital centres in Cote d’Ivoire. Serum obtained allowed the determination of anti-ICA autoantibodies by the immunofluorescence method, anti-GAD and anti-IA2 detected by ELISA. Blood parasites were sought by the drop of thick and blood smears. Intestinal parasites were searched by the direct method, Kato and Ritchie techniques. Yeasts isolation was done on Sabouraud chloranphénicol and identifying by the chromatic Candida medium. Pinworms were sought by the anal scotch test technique. Vaccines and food were mentioned on a survey sheet.
Results: The 3 diabetes autoantibodies were present in T1D and 2 combinations anti-GAD-IA2 among siblings (p<0.0001). Hand pinworms, DT1 and their siblings infected with blood parasites are respectively, intestinal parasites, yeast. The diet of T1D significantly different from that of siblings (p=0.031<0.05). Conclusion: There is no correlation between the presence of diabetes autoantibodies and blood and intestinal parasites, yeasts, pinworms among siblings of diabetics. Their diet should be balanced to avoid the installation of diabetes.

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