Self-efficacy is the belief of person about his or her ability and capacity to accomplish a task or to deal with the challenges of life. Since, Self-efficacy is an important factor for mothers who are caring their children. Aim: This study aimed to compare the effect of a simulation-based and video-base methods on mothers’ self-efficacy in bathing their preterm infants. Methods and Material: In this Randomized Controlled Clinical Trial, 90 first time mothers were chosen by convenience sampling method and divided into three groups using simple random sampling. Selfefficacy questionnaires were completed by mothers before the intervention. In simulation group, infant bathing training went on 15 minutes for the group on moulage and in the video group the training went on for 15 minutes for the group by playing the video. Control group did not receive any training in this regard. Again, after 45 hours of intervention and a week after discharge mothers’ self-efficacy in all three groups were evaluated. In order to evaluate the change at different intervals repeated measures analysis of variance was conducted on the data. Results: Results showed that mothers’ self-efficacy before and after the intervention have a significant increase in both simulation and video groups (P<0.001). Mothers’ self-efficacy score in simulation and video groups showed a significant difference with control group (P<0.001). But the Tukey’s test showed no significant difference between simulation and educational video group (P=0.159). Conclusions: Based on the findings, both simulation and video helped the mothers to increase their self-efficacy in bathing preterm infant. Thus, health centers can adopt either method for training mothers according to their facilities or equipment for better preparing them for looking after their preterm infants
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