Abstract

Chronic Effects of Quetiapine, Paliperidone, Iloperidone and Loxapine on Mice Isolated Detrusor Smooth Muscle

Objective: Quetiapine, paliperidone, iloperidone, and loxapine are used for the treatment of patients with schizophrenia, the current study aimed to identify the effects of atypical antipsychotic drugs quetiapine, paliperidone, iloperidone, and loxapine in mice isolated bladder using the organ bath system. Methods: 63 male inbred mice were used in this study. Mice were treated by i.p. injection of drugs for 21 days. Then, the effects of drugs were investigated on isoproterenol-induced relaxation responses of carbachol-induced contractions in isolated detrusor strips. First, the detrusor strips were stimulated with KCl, and then tissues were washed for a further 30 min and pre-contracted with a submaximal concentration of carbachol. After the contraction reached the plateau, cumulative concentrationresponse curves to isoproterenol were obtained. The significance of differences was tested by one-way ANOVA with a Tukey post hoc test. Results: We showed that carbachol-induced contractions dose-dependently relaxed by isoproterenol in mice detrusor strips obtained from quetiapine, paliperidone, iloperidone, and loxapine treated group. However, none of the drug treatments showed an effect on the KCl responses of mice bladder. Conclusion: Quetiapine, paliperidone, iloperidone, and loxapine increased the isoproterenol-induced relaxations of the detrusor smooth muscle that increased the bladder capacity. We demonstrate that quetiapine, paliperidone, iloperidone, and loxapine may represent a potential drug for patients with overactive bladder. These drugs might be clinically useful for the treatment of overactive bladder in patients that should use antipsychotic drugs. These findings open a new approach to developing drugs for overactive bladder in the future.

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