Abstract

Association of Secreted Frizzled Related Protein-4 (SFRP-4) and Adiponectin (APN) in the Early Stage Progression of Insulin Resistance in Pre-diabetic Obese Subjects

Background: Pre-diabetes is a condition characterized by increased plasma glucose levels that fall somewhere between normoglycemia and hyperglycemia. It can be caused by the derangement in the fasting glucose, glucose tolerance, or both. SFRP-4 (Secreted Frizzled-Related Protein-4) is extensively expressed in adipose cells and beta cells of the pancreas, and its levels are elevated many years before diabetes is diagnosed. Adiponectin (a peptide hormone) is secreted by the adipose tissue that was reported to have insulin-sensitizing properties. Aim: To compare the levels of serum SFRP-4 and serum adiponectin in pre-diabetic obese subjects to the levels in control subjects. We also studied the correlation of serum SFRP-4 and serum adiponectin with anthropometric parameters, IGT, fasting blood glucose, and lipid profile. Materials and Methods: There were 200 pre-diabetic and 100 non-diabetic participants in the present study. Serum SFRP-4, serum adiponectin, fasting blood glucose, IGT and lipid profile were all measured in blood samples. Subjects were categorized into two groups based on their BMI into control and case. The Control group was healthy individuals with a mean of BMI, 24.87 kg/m², and the case group was having pre-diabetes and obesity with a mean of BMI, 30.80 kg/m². During the screening period, anthropometric parameters were measured using standard techniques. Results: Mean serum SFRP-4 and serum adiponectin were statistically significant and were different in control and case groups (p˂0.001). Conclusions: Present study shows a strong relationship between serum SFRP-4 and serum adiponectin in cases and controls.

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