Abstract

Association between Platelet to Lymphocyte Ratio to ROP in a Preterm Neonate in a Tertiary Centre in Northern India: A Retrospective Observational Study

Objective: To figure out association between Retinopathy of Prematurity (ROP) and Platelet to Lymphocyte Ratio (PLR).

Methods: A retrospective observational study was conducted, in tertiary care NICU where screening for ROP from January 2021 to December 2021 was done as per institutional protocol. Neonates who were born preterm ≤ 34 gestational weeks with ROP were enrolled as the observation group and neonates with no ROP were enrolled as the control group, whose complete blood cell were measured within the first 24 h of life. The levels of PLR were studied in all groups.

Results: In this study, 20 cases of ROP were enrolled and 20 cases of no-ROP as controls. The median PLR values were 75.99 (IQR, 50.43-87.11) in the ROP group and 69.24 (IQR, 55.52-88.12) in the non-ROP group, but the difference between groups was not statistically significant (P=0.104).

Conclusion: Our study has shown that higher PLR inpreterm neonates admitted in NICU in first day of lifecan be evaluated as a biochemical marker for predicting ROP early.

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