Background: The Corona Virus Disease-19 is a type of viral disease that is threatening the socio-economy, health, education, and politics across the world including Ethiopia. Objectives: To assess the probable impact of the Coronavirus disease-19 across Ethiopia in the main principal sectors from 2019 to 2020. Methods: The review of existing information was employed for the analysis. Accordingly, the information gathered was synthesized and described in the case of health facilities, education, economics, politics, and social. Results: As a result of COVID-19, the real Ethiopia’s Gross domestic product (GDP) decreased to 6.2% (in 2020) from 9.0% (2019). Moreover, a highpitched weakening in tourism sectors with the hotel industries tenure rate decreased to 2%, and significant job losses for Ethiopia were estimated between 700,000 and 2,000,000. Moreover, the review showed that due to this pandemic about 1.2 million; 3.2 million, and 238 thousand children faced without oral antibiotics for pneumonia; Diphtheria, Tetanus, Pertussis (DPT) vaccinations; and access to facilities, respectively in Ethiopia. In addition, only 2.2 million women received family planning services from health sectors across Ethiopia. As the evidence showed, at a national level, more than 26,000,000 students were out of school; general elections were didn’t held on the scheduled date, and many of the society are causing disruptions. Conclusions: Thus, COVID-19 has the potential to decrease the economy, disturb healthcare facilities, quality of education, trouble politics, and social pattern, which need to prevent and control the integration of individuals into the government.
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