Background: Mucormycosis is a fatal opportunistic infection caused by filamentous fungi, Mucoromycete’s of the family Mucoraceae, also called as black fungus. There were mounting number of cases reported mainly during the second wave of the pandemic, even in mild and asymptomatic cases who had recovered from COVID-19 due to the immunocompromised state caused by the disease and its treatment.

Aim and objectives: Through this study, we aim to study the clinical features and clinical outcomes of patients diagnosed and treated for Rhino-Orbito Cerebral mucormycosis.

Materials and methods: This is a descriptive cross-sectional study conducted among 42 patients with a confirmed diagnosis of rhino-Orbito cerebral mucormycosis with post COVID-19 infections. The medical records were retrieved and the demographic findings along with clinical, histopathological and radiological data were reviewed.

Results: The mean age of the study patients was 54.71 ± 10.11 years with majority of males (81%). Regarding the co-morbid conditions, 85.7% of the study participants had a history of diabetes mellitus and 33.3% had hypertension. 81% patients received oral/IV steroids for the management of COVID-19. Regarding the presentation of symptoms, facial complaints and nasal complaints were noted in 81% patients. Ocular complaints were present in 71.4% patients and intracranial invasion features were reported from 28.6% patients. Adequate local debridement along with FESS was done in 76.2% patients. Recurrence was seen in 42.9% patients. Regarding mortality, 19% patients died.

Conclusion: New-onset of headache, facial/cheek swelling, black nasal discharge, periorbital swelling, visual diminution and restriction of eye movements should prompt an abrupt search for mucormycosis especially in those having history of diabetes mellitus with recent or current COVID-19 disease. Prompt diagnosis with early surgical intervention in adjunct to aggressive anti-fungal treatment could halt the spread of infection to other adjoining areas and improves the outcome.