Complications of Diabetes such as Fatigue is a serious obstacle hindering the enhancement of health behaviors, including participation in Diabetes self-care programs, and is considered as a challenging problem for nurses and health-care providers in the process of diseases’ treatments and therapies. These complications not only influence the patients’ quality of life, but also, increases the risk of complications. Hence, regarding the importance of the role of fatigue and its subsequent effects on Diabetes’ control as well as the paucity of studies carried out in this field, the current research intended to review fatigue condition in patients with type II Diabetes in Isfahan Endocrine and Metabolism Research Center. The nature of this study is a Quantitative-Descriptive research. For the purpose of the present study, 195 patients with type II Diabetes were selected as the target sample population, based on Non-probability Convenience Sampling Method, from Isfahan Endocrine and Metabolism Research Center. To collect the research data, the researcher used a two-part written questionnaire encompassing Personal Information and Multidimensional Fatigue Symptom Inventory- Short Form (MFSI-SF) as the data collection tool. Each of the participants in the present research were briefly advised about the nature and objectives of the research and they were interviewed by the researcher to complete the questionnaire after consent reached with the patients. The collected data was analyzed by SPSS16 statistical analysis software; accordingly the significance level of all the tests was estimated as PÃ?â?¹Ã?â??0.05. The results of the data analysis showed that %85.1 of the patients suffered from fatigue. There was a statistically significant difference between the mean of the severity of fatigue condition between female and male patients in the present study, i.e.23.22 ± 17.49 for women and 13.24 ± 17.73 for men, indexing a significance level of PÃ?â?¹Ã?â??0.05. Furthermore, the highest score amongst the Multidimensional Fatigue yielded 6.80 ± 5.44 and 9.32 ± 5.33 respectively for the General Fatigue Dimension in male patients and Emotional Fatigue Dimension in Female Patients. Considering the increasing spread of fatigue in patients with Type II Diabetes, proper actions for prevention, diagnosis and treatment of fatigue symptoms can have a significant effect on Diabetes Control and effectively enhance the quality of nursing services and nursing cares of patients with Diabetes. As a consequence, it is recommended that health-care providers, particularly Community Health Nurses, pay the most attentions to this critical point in caring and training the suffering patients with Diabetes
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