International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Zuhair A Muhi-eldeen
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, University of Petra, Amman, JordanPublications
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Research
Designs, synthesis, structural elucidation and antimicrobial evaluation of various derivatives of 2-mercaptobenzimidazole as possible antimicrobial agents
Author(s): Rand Al-kazweeny, Zuhair A Muhi-eldeen, Elham Al-kaissi*, Sadeq Al-tameemi, Sumia S Tayeh and Jaafar Al-hussenini
Objective: Derivatives of 2-Mercaptobenzimidazole (2-MBI) are very significant heterocyclic compounds. 2-MBI and its derivatives have been showing different biological activates, the most significant activity exhibiting the antimicrobial activity. The aim of the project includes the synthesis of new derivatives of 2-MBI. Methods: Formation of 2-(Phenethylthio)-1H-benzo[d] imidazole (ZR-1) by alkylation, thioester S-(1H-benzo[d]imidazol-2-yl) O-ethyl carbonothioate (ZRJ2), S-(1H-benzo[d]imidazol-2-yl) O-isobutyl carbonothioate (ZR-4), and S-(1H-benzo[d] imidazol-2-yl) O-methyl carbonothioate (ZR-8), the reaction involves thio acetic derivative 2-((1H-benzo[d]imidazol2-yl) thio) acetic acid (ZR-3) with oxalyl chloride to generate acyl derivatives to this added cyclic amines to yield compounds, amid derivatives 2-((1H-benzo[d]imidazol-2-yl) thio)-1-(2, 6-dimethylpiperidin-1-yl) ethan-1-o.. Read More»
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