International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Tejaswi
Department of School of Medical and Allied Sciences, GD Goenka University, Haryana, IndiaPublications
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Review
Contaminations and Immune System Infections
Author(s): Tejaswi and Amit Nayak*
The considerable prevalence of disease-discordant pairs among monozygotic twins underscores the pivotal role of environmental factors in the development of autoimmune diseases. Initial efforts were focused on identifying triggering factors, which have been found to include infections in animal models. For instance, the Coxsackie B4 virus has been linked to type I diabetes, while the encephalomyocarditis virus is associated with autoimmune myositis. In these models, viruses are thought to increase the immunogenicity of autoantigens by inducing local inflammation. In addition, there are cases of mimicry between microbial and human antigens. For instance, the induction of Guillaine-Barre syndrome in rabbits through immunization with a peptide derived from Campylobacter jejuni is explained by the similarity between C. jejuni antigens and peripheral nerve axonal antigens. In other models, .. Read More»
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