International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Seymanur Basarir
Pharmacology Department, Sakarya University, Sakarya, TurkeyPublications
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Research
Effects of Pyroglutamyl Peptides on Depression, Anxiety and Analgesia in Mice
Author(s): Oguz Mutlu*, Pelin Tanyeri, Seymanur Basarir, Ibrahim Uygun, Furuzan Akar, Gulsen Celebi, Mehmet Emin Buyukokuroglu, Faruk Erden and Karel Vales
Objective: Insect Adipokinetic Hormones (AKH) play role in sugar and lipid mobilization and support the production of energy for the flight and movement of insects. In our previous studies, we showed that AKH had antidepressant, anxiolytic, and analgesic effects in mice and increased neurotrophic factors and neurogenesis in mice, and had beneficial effects in olfactory bulbectomy and posttraumatic stress disorder rat models. In our previous study, we hypothesized that metabolites of AKH, including pyroglutamic acid and pyroglutamyl peptides, pass the blood-brain barrier after intraperitoneal administration of AKH in rats, which is supported by other studies. Methods: In this study, we aimed to investigate the effects of three pyroglutamyl peptides on depression, anxiety, and analgesia in the Forced Swimming Test (FST), Elevated Plus Maze (EPM) test, and hot plate test in mice. We used.. Read More»
DOI: O
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