International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Norhida Ramli
Medical Lecturer of Basic Medical Sciences, University Malaysia Sarawak, MalaysiaPublications
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Research
Effects of Circadian Rhythm Disruption on Cognitive Function and Related Expression of DREAM and Hyperphosphorylated Tau Protein in the Rat's Hippocampus
Author(s): Norhida Ramli*
Introduction: Sleep deprivation has been demonstrated to impair the cognitive function associated with Downstream Regulatory Element Antagonistic Modulators (DREAM), Brain-derived neurotrophic factor (BDNF), and cAMP-response element binding (CREB) protein expression changes in rat hippocampus. This study was conducted to investigate whether Circadian rhythm Disruption (CD) has a similar mechanism with sleep deprivation on cognitive function and DREAM, Tau, and hyperphosphorylated Tau protein expression changes. Methods: 24 male Sprague Dawley rats were equally divided into 3 groups: (i) control (C), (ii) Acute CD (ACD), and (iii) Chronic CD (CCD). 1 cycle of the CD consists of phase-shifting, where daily light off was phased advanced three hours daily for 6 consecutive days followed by ten days of re-entrainment for recovery. The acute CD was induced.. Read More»
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