International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Mohammad F. Fazaludeen
Fin Vector, Kuopio, FinlandPublications
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Research
Exome Sequencing on Illumina Platform revealed Relation between Nucleic Acids Interconversion and the Ratio of Transition/Transversion in Chronic Kidney Disease (CKD) Patients
Author(s): Edem Nuglozeh* and Mohammad F. Fazaludeen
Aims: Renal Failure and Chronic Kidney Disease (CKD) represent major health problems that affect more than 10% of the general population worldwide amounting to more than 800 million individuals. CKD is a congruence of many diseases like Diabetes, Hypertension, hypercholesterolemia, and different cardiovascular diseases as well as epigenetic factors contributing to the development of this Disease. We undertook this work as a pilot study to establish a database of genetic variants for novel or existing genes involved in the development and progress of CKD in the Saudi population. Methods: Patients' blood samples of 12 donors suffering from CKD were used to perform the Whole Exome Sequencing (WES) on genomic DNA on the Illumina Platform. Bioinformatics algorithms were used to perform different callset to explore different mechanisms such as nucleic a.. Read More»
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