International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Mesheil Alalyani
College of Applied Medical Sciences, Al-Ghad University, Abha, Kingdom of Saudi ArabiaPublications
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Research
Role of CaMKII in Controlling the Morphology and Motility of Neurite Growth Cone in Lymnaea stagnalis Neurons
Author(s): Atiq Hassan, Nazim Nasir*, Khursheed Muzammil, Mesheil Alalyani and Mohammed Rehan Asad
Calcium ion (Ca2+) and Calmodulin (CaM) are important signaling molecules that have been shown to play a significant role in a wide variety of neuronal functions, including neurite outgrowth of axon and dendrites. The growth cone is located on the tip of the growing neurite. The morphology and motility of the growth cone depend on Ca2+ and the stimulation of Ca2+ dependent protein kinases (CaMK) in developing neurons. CaM-kinase II (CaMKII) is a member of the CaMK family, and it is highly expressed in the cytosol of developing neurons, including the growth cone. We hypothesized that CaMKII activity could be necessary for growth cones morphology and motility. To test this possibility, the identified Pedal A (PeA) neurons from the central ring ganglia of the freshwater pond snail Lymnaea stagnalis were cultured for 24 hrs -48 hrs in a 2 ml brain conditioned medium. Following neurite out.. Read More»
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