International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Mehmet Emin Buyukokuroglu
Faculty of Medicine, Department of Pharmacology, Sakarya University, Sakarya, TurkeyPublications
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Research
Chronic Effects of Quetiapine, Paliperidone, Iloperidone and Loxapine on Mice Isolated Detrusor Smooth Muscle
Author(s): Mehmet Hanifi Tanyeri, Mehmet Emin Buyukokuroglu, Pelin Tanyeri*, Rumeysa Keles Kaya, Seyma Nur Basarir Bozkurt, Oguz Mutlu, Furuzan Yildiz Akar, Bekir Faruk Erden and Guner Ulak
Objective: Quetiapine, paliperidone, iloperidone, and loxapine are used for the treatment of patients with schizophrenia, the current study aimed to identify the effects of atypical antipsychotic drugs quetiapine, paliperidone, iloperidone, and loxapine in mice isolated bladder using the organ bath system. Methods: 63 male inbred mice were used in this study. Mice were treated by i.p. injection of drugs for 21 days. Then, the effects of drugs were investigated on isoproterenol-induced relaxation responses of carbachol-induced contractions in isolated detrusor strips. First, the detrusor strips were stimulated with KCl, and then tissues were washed for a further 30 min and pre-contracted with a submaximal concentration of carbachol. After the contraction reached the plateau, cumulative concentrationresponse curves to isoproterenol .. Read More»
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