International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Kainat Aftab
Department of Biotechnology, University of Central Punjab, Lahore, Punjab, PakistanPublications
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Research Article
A CRITICAL CORRELATION BETWEEN ARSENIC TOXICITY AND RISK OF TYPE 2 DIABETES
Author(s): Kainat Aftab, Huda Rehman Mir*, Manam Walait and Mahida Mehmood
Arsenic is considered one of the most lethal elements to humans because of its adverse health effects. Worldwide arsenic is contaminating groundwater and it has been reported in different areas of the world that drinking water carries Arsenic into the human body. That has helped researchers develop a link between exposure to Arsenic due to drinking water and the prevalence of diabetes. When Arsenic enters the body, the human gene AS3MT plays a pivotal role in its methylation and metabolism. The intronic and exonic single nucleotide polymorphisms in the AS3MT gene show heterogeneity due to inter-individual variation. To note that type 2 diabetes is a disorder caused by insulin resistance, hyperglycemia and a change in insulin secretory capacity of pancreatic β cells. The exposure to chronic levels of Arsenic interferes with the transcriptional factors involved.. Read More»
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