International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Hany A El Kattawy
Medical Physiology Department, College of Medicine, Zagazig University, EgyptPublications
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Research
Calcitriol Reduces the Contractile Response of Isolated Rabbit Ileum
Author(s): Hany A El Kattawy* and Shimaa Hadhod
Background: 1, 25-dihydroxycholecalciferol [1a, 25(OH)2D3], known as calcitriol, is the active metabolite of vitamin D3 that regulates calcium and phosphate homeostasis. Calcitriol plays a key role in the regulation of immune, cardiovascular and nervous systems. Moreover, it regulates cell proliferation and differentiation with even anti-aging activity. Its action is mediated by the vitamin D receptor found in nearly almost all types of cells providing multiple actions on various tissues. Objectives: This study examined whether calcitriol could change the motility of the isolated rabbit ileum segments and investigate its mechanism of action more thoroughly. Methods: Different serial doses of calcitriol were studied on the isolated ileal smooth muscles of the rabbit in the presence and absence of L-NAME (a nitric oxide synthase inhibit.. Read More»
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