International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Gholamhossein Tamaddon
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IranPublications
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Research
Effects of L-asparaginase on The Expression of EBF1 Gene, miR-181b, and miR-17 and Its Association with Apoptosis in the Nalm-6 Cell Line
Author(s): Golnaz Minaeeian, Reza Ranjbaran, Parisa Tandel, Farahnaz Zare and Gholamhossein Tamaddon*
Background: L-asparaginase is one of the most important and common drugs in the treatment of children and adults with acute lymphoblastic leukemia. Transcription factors play a key role in the prognosis, treatment, and recurrence of cancer. The EBF1 transcription factor is essential for B cell commitment and differentiation. Moreover, miRNAs are involved in many cellular processes such as cancer. Aim of the work: This study aimed to evaluate the effect of L-asparaginase on the EBF1 gene, miR-181b, and miR-17 expression and to examine its relationship with apoptosis in the Nalm-6 cell line. Material and Methods: In this experimental study, the Nalm-6 cell line was cultured in optimal condition, and treated with L-asparaginase. An ideal concentration of L-asparaginase for the Nalm-6 cell was determ.. Read More»
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