International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Ebube S Chidera
Lagos State University, NigeriaPublications
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Research
Molecular Docking Study of Selected Bio-Active Compounds on Alzheimer's Disease using BACE-1 (Pdb ID: 5QCU) as Target Protein
Author(s): Ebube S Chidera, Ashish B Gulwe* and Awote O Kayode
Alzheimer’s Disease (AD) is a complex neurodegenerative disease that is characterized by the accumulation of amyloid-beta (Aβ) peptides in the brain. It is the most common type of dementia which begins with mild memory loss and leads to severe decline in one’s ability to hold adequate conversation and response with the environment. β-secretase-1(BACE-1) is a key enzyme involved in the production of Aβ peptides, making it an attractive target for drug discovery in AD treatment. Herein, this study aimed to investigate the anti-alzheimer’s potential of selected bioactive compounds against BACE-1 protein. Molecular docking was employed using Pyrx and Biovia discovery studio software to predict potential selected bioactive antagonists and non-covalent interactions between the selected ligands, standard drugs and the target protein. BACE-1 target protein was.. Read More»
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