International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Alla Shabalina
Laboratory of Hemorheology and Hemostasis, Research Center of Neurology, 80,Volokolamskoye Shosse, Moscow, RussiaPublications
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Research
MicroRNA Expression in Patients with Advanced Carotid Atherosclerosis
Author(s): Anton Raskurazhev*, Marine Tanashyan, Alla Shabalina, Anastasia Kornilova and Polina Kuznetsova
Background: Carotid Atherosclerosis (AS) is a major cause of cerebrovascular pathology. Our study aimed to identify in peripheral blood the expression levels of several miRs (miR-126-(5p/3p), miR-29a-(5p/3p), miR-33a-(5p/3p), miR- 21-(5p/3p)), involved in AS, in patients with advanced carotid atherosclerosis. Methods: Overall 50 patients (median age 66 (61; 71) years, 58% male) were enrolled in this study, and were divided into 2 sub-groups by percentage of stenosis in the Internal Carotid Artery (ICA): ≥50% (group I) and less than 50% (group II). Clinical characteristics, comorbidities, and miRs expression level were estimated. Results: The expression levels of most microRNAs were statistically different between groups, with miR-126-5p/3p, miR-29-3p and miR-21-3p lower in Group I (5.7 (4.8; 6.62) vs. 9.4 (8.1;.. Read More»
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