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Urticadioica attenuate effect of Doxorobicin‐Induced changes on sperm parameters in the mice

Authors: Zahra Baninameh, MiladMoloudizargari, HojjatGhasemnejadBerenji, SedigheRezaie-Chamani, VajiheHassanzadeh,Margherita Ferrante, ShokoofeAzarbahra and HeidarHeidariKhoei

Int J Med Res Health Sci.116-121 | pdf PDF Full Text

Doxorubicin (DXR) is used as an antitumor agent for the treatment of human neoplasm. The use of DXR has
adverse effect on reproductive system including testicular toxicity and alteration in semen quality. The aim of this
study was to evaluate the protective effects of
Urtica dioica against DoxorobicinInduced changes on sperm
parameters. 24 male mice were randomly divided into 4 groups. Control group received normal saline solution
throughout the course of the study. Urtica dioica (UD) control group, received UD (100 mg/kg body weight) thrice
in a week and DOX (3 mg/kg body weight) once in a week injected intraperitoneally in Doxorubicin (DXR) control
group and Urtica dioica- Doxorubicin (UD-DXR) group, received Urtica dioica (100 mg/kg body weight) three
times in a week and DOX (3 mg/kg body weight) once in a week through the route for a period of 2 weeks. At the
end of experimental period, all animal were sacrificed by cervical dislocation, their epididymes were removed and
sperm analysis were done. In mice with DXR administration, epididymal sperm motility, progressive motility, sperm
count and viability significantly decrease while sperm cells with abnormal morphology significantly increase when
compared with control groups. Co-treatment with UD attenuate toxicity effect of DXR and improve sperm
parameters. Results of our study showed that UD diminished DXR-induced testicular toxicity and improve semen
parameters, thus suggesting its co-administration as a protective agent during doxorubicin treatment. Further
studies should be aimed to determine protective effect of UD against chemotherapeutic agents such as DXR.

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