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TORCH infections susceptibility in Iraqi Patients with Multiple Sclerosis

Authors: FadwaGhassan, Wassan Abdul Kareem and ThamerMutlagJasim

Int J Med Res Health Sci.301-305 | pdf PDF Full Text

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Several disease-modifying
therapies have been shown to ameliorate the disease course; however, the individual treatment response and the
occurrence of adverse events remain highly unpredictable. In the last 2 decades, a multitude of studies have aimed
to identify biomarkers that enable treatment allocation in the individual patient or subgroup of patients with regard
to treatment efficacy and safety profile. To investigate the TORCH infection susceptibility and tin patients with
multiple sclerosis. Thirty Iraqi newly diagnosed patients with MS and follow them after one month of treatment (
Beta interferon inj. I inj./ week) and compare the results with 20 healthy control. . Females patients(pre treatment
group) showed was a highly significant difference(p<0.0001) when compared to control,while in male patients, no
significant difference was noticed when compared to control(p>0.05). Rubella percent of infection, the female
patients(pre-treatment group) was highly significant difference(p<0.0001) when compared to control as well as, in
male patients ,a significant difference was noticed when compared to control(p<0.0001).CMV infection, the female
patients(pre-treatment group) was highly significant difference(p<0.0001) when compared to control, table(3) also,
in male patients, a significant difference was noticed when compared to control(p<0.0001). The resule of the study
showed a possible association between CMV infection and MS. Further experimental and epidemiological studies
using case-control approaches are needed to confirm this association.Various additional observations also indicate
a protective effect of CMV on autoimmune diseases. CMV immune evasion may mitigate the autoimmune reactions
and proinflammatory milieu that contribute to MS.

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