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The protective effect of Aloe vera on paraquat hepatotoxicity

Authors: Morteza Pourahmad, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Mohammad Hadi Sameni1, Hassanali Abedi, Zahra Khabbaz Kherameh, Sara Mohammadi and Marzieh Alsadat Hosseini

Int J Med Res Health Sci.253-258 | pdf PDF Full Text

Paraquat is a common herbicide that is used in agriculturem, and Liver damage is a severe complication after its
consumption in mammals, which can be prevented by antioxidants. With due attention to the various nutritional
materials and antioxidants in aloe vera (a medicinal plant), evaluation of its effect on prevention of paraquat
induced hepatotoxity was the goal of this study. In this experimental study, 72 Wistar male rats were randomly
divided into control, sham, and 7experimental groups. In experimental groups paraquat with various doses of aloe
vera is given to the mice for 2 weeks. After that liver enzymes and histologic changes were compared in different
groups. In first experimental group (in which paraquat alone was administered), aspartate transaminase (AST),
alanine transaminase (ALT), and alkaline phosphatase (ALP) concentrations were significantly elevated in compare
to the control and sham groups (p<0.05). In addition histologic destruction was significant in this group. On the
other hand, in experimental groups in which paraquat were administered plus aloe vera liver enzymes were
significantly low. In addition histologic structure was preserved in groups in which aloe vera was administered in
compare with paraquat alone group. In this study; we concluded that, Aloe vera extract, probably due to its strong
antioxidant property, could reduce the destructive effects of Paraquat on the rat liver.

Keywords: Aloe vera, Paraquat, liver, rats

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