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The prevalence of TTV and SEN-V among children who borned from HIV-infected mothers

Authors: Rouhi Afkari, Hamid Reza Galavi, Narges Arbabi, Abdollah Taheri, Eghbal Sekhavati and Fateme Lotfi Mola

Int J Med Res Health Sci.158-163 | pdf PDF Full Text

Women may have persistent risk of HIV acquisition during pregnancy and postpartum . Children acquire infection
through mother-to-child transmission (MTCT) either during pregnancy, delivery, or by breast-feeding .evaluating
risk of HIV during these periods is important to inform optimal prevention approaches. The aim of this study was to
determine the prevalence of TTV and SEN-V among children who borned from HIV-infected mothers by multiplexnested-RT-PCR protocol and ELISA test. Samples were obtained from 100 infants born with HIV- infected mothers.
Infants were followed to 18 months of age and plasma was stored within 7 days of birth, at 2, 5, 6, and 8 weeks, and
3, 6, 9, 12 and 18 months. Mothers and their Infants were tested for HIV ,SEN Virus and TTV using multiplexnested-RT-PCR protocol. In this study, Of 100 children ( Female=59, Male=41 ) were born from mothers with HIV
who samples were collected after birth. Examined using PCR technique showed of 150 mother who were infected
with HIV, 72/150(48%) SENV and 63/150 (42%) TTV . While PCR results showed that infants were infected with
HIV,58%TTV positive and 48% SENV positive. In weeks 5 and 10 samples were collected from all infants and were
analyzed by PCR technique. There was no difference in the results compared to the seventh day. If babies born with
HIV were treated with the ART drugs. There was a high frequency of late diagnosis in this patient cohort. Earlier
diagnosis is an important measure for controlling HIV among children and also the results showed that pregnant
women with HIV, if, according to a regular schedule ART drugs are prescribed. Reduced risk of transmission to

Keywords: HIV, MTCT, SENV, TTV

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