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The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women

Authors: SimaKiani rad, Sedighe Forouhari, Alamtaj Samsami Dehaghani, HomeiraVafaei, Mehrab sayadi and Maryam Asadi

Int J Med Res Health Sci.257-263 | pdf PDF Full Text

Hot flashes and night sweats associated with menopause are the most annoying symptoms among premenopausal
women and have been ranked as the first reason for referral to medical centers. The common treatment for this
symptom is administration of Hormone Replacement Therapy (HRT) that has some adverse effects and is sometimes
contraindicated. Therefore, use of herbal drugs that have fewer side effects needs to be investigated. This study
aimed to investigate the influence of salvia tablets on hot flashes, night sweats, and estradiol hormone in
postmenopausal women referring to healthcare centers in Shiraz. This double-blind randomized clinical trial was
performed on 100 qualified postmenopausal women with hot flashes. The study women were divided into two groups
daily treated with 3 salvia or placebo tablets (100 mg) for 8 weeks. Estradiol hormone and menopause symptoms
were evaluated using Menopause Rating Scale(MRS)1 week before and 8 weeks after the beginning the intervention.
Besides, duration, intensity, and frequency of hot flashes and night sweats were evaluated every week, and the two
groups were compared in terms of these variables. The results showed no significant difference between the two
groups regarding demographic information, hot flashes, night sweats, and other menopause symptoms in MRS scale
before the intervention. After 8 weeks, however, hot flashes, night sweats, and MRS scores significantly decreased in
the saliva group compared to the control group. However, no significant difference was observed between the two
groups concerning the estradiol levels. Yet, the results of intra-group analysis showed that the level of this hormone
increased in the sage group. Sage tablets were effective in treatment of hot flashes, night sweats, and other
menopausal symptoms in postmenopausal women. Thus, they can be considered as an alternative therapy for the
individuals who are not able to use HRT.
Keywords: Saliva, Hot flashes, Night sweating, Estradiol

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