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The effect of intense intermittent training with and without taking vitamin E on mRNA expression of p53/PTEN tumor suppressing genes in prostate glands of male rats

Authors: Mohammad Esmaeil Afzalpour, Nader Tanideh, Masood Sepehrimanesh and Amin Allah Dashtiyan

Int J Med Res Health Sci.521-528 | pdf PDF Full Text

Physical activity and diet are the most important modifiable determinants of cancer risk. The objective of this study
was to examine the effect of intense intermittent training with and without taking vitamin E on expression of p53 and
PTEN tumor suppressing genes in the prostate gland of male rats. For this purpose, 50 Sprague-Dawley male rats
were randomly assigned into 5 groups: [1] control (CON, n = 10), [2] sham (S, n = 10), [3] intense intermittent
training (IIT, n = 10), [4] intense intermittent training + vitamin E (IIT + VE, n = 10), [5] vitamin E (VE, n = 10).
Protocol of this study was implemented for 6 days per week for 6 weeks, with observing the overload principle on
the motorized treadmill. After implementing training protocol, expression rate of p53 and PTEN genes reduced
significantly (p<0.000, p<0.031, respectively). Taking vitamin E with intermittent training caused significant
reduction in p53 expression (p<0.013), while it caused significant increase in expression of PTEN (p<0.035). These
results showed that intense intermittent training reduces expression of p53 and PTEN tumor suppressing genes and
taking supplementation vitamin E along with this type of training could cause different effects in expression of these
tumor suppressor genes.

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