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The effect of Biochanin A on the expression of Adiponectin in adipose tissue of Streptozotocin-Nicotinamide induced diabetic rats

Authors: Darya Ghadimi, Mohammad Taghi Goodarzi, Nasrin Ziamajidi and Shirin Moradkhani

Int J Med Res Health Sci.223-230 | pdf PDF Full Text

ABSTRACT
Increased plasma level of adiponectin can improve insulin resistance in skeletal muscle cells. Activation of PPARĪ³
transcription factor can increase the expression of adiponectin gene and adiponectin level. Biochanin A, a natural
compound, is a PPARĪ³ agonist. The aim of this study was to investigate the effect of Biochanin A administration on
adiponectin expression, insulin resistance and control of type 2 diabetes mellitus. Adult male Wistar rats were used
in this study. Induction of type 2 diabetes mellitus was performed by single intraperitoneal injection of
Streptozotocin-Nicotinamide. Animals were randomly divided into 8 groups and Biochanin A was administrated for
a month at 4 different doses: 1 and 5 mg/kg IP, 10 and 20 mg/kg orally. Some biochemical parameters such as
fasting blood glucose, plasma insulin and HOMA index were measured. Adiponectin level in adipose tissue was
examined by western blotting analysis. Results of the present study demonstrated that Biochanin A consumption at
doses of 5mg/kg IP, 10 and 20mg/kg orally decreased the fasting blood glucose level, increased adiponectin level in
adipose tissue and improved insulin resistance significantly. Based on findings of present study, it can be concluded
that increased adiponectin level in adipose tissue accompanies with improved insulin resistance.
Keywords: Insulin resistance, Type 2 diabetes mellitus, Adiponectin, Adipose tissue, Isoflavonoid, Biochanin A

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