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The effect of adding Pregabalin to Conventional Treatment in schizophrenia Patients, for improving Positive, negative and general symptoms of These Patient

Authors: TalatJavahery, AfshinTayyebi and Mohamad Reza Belyad

Int J Med Res Health Sci.282-287 | pdf PDF Full Text

Schizophrenia is a complex and heterogeneous disorder, with multiple, and varying symptoms. For this very reason
it cannot be distinguished based on inherent disorder process, effects of medication therapy, or continuous longterm
hospitalization. To date, much effort has been made to identify drugs, effective in the treatment of its symptoms.
Yet, despite great progress made in this path, treatment of these symptoms has not had any significant success. Thus,
the aim of the present study is to examine the effect of adding the drug Pregabalin to the customary drugs of the
patients with schizophrenia for improvement in positive, negative, and general signs of these patients. The method
used, in this study, was quasi-experimental. The type of objective was functional, having pre-test – post-test design,
with a control group. The population, in the study, consisted of 60 schizophrenic patients, hospitalized in the
serenity center, who had been diagnosed according to the standards of DSM – 5, and were placed on a fixed dose,
of customary medications, for a minimum of 2 months. 30 individuals were selected according to random table, and,
on that basis, were placed in two groups of test and control, with 15 members each. The measurement instrument
used was PANSS. Pre-test was performed by having all 30 patients filling out the PANSS questionnaire. Then,
Pregabalin (50 mg.) was administered, to the test group, two times a day, for a period of 6 weeks. No medication
was added to that of the control group. Following a two-week period, both groups were reassessed using PANSS
test. The obtained results were analyzed using covariance analysis, using SPSS software. Results of the study
indicated that adding Pregabalin did not result in improvement in any of the symptoms (positive, negative, general,
agitation, anxiety, and depression) in schizophrenia patients. The study results indicated that although symptoms
(positive, negative, general, agitation, anxiety, and depression) were lowered in patients with schizophrenia, but this
decline was not significant, and no significant difference was observed between the two groups of test and control.

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