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The effect of 17α-HydroxyprogestroneCaproate on prevention of preterm labor in high-risk pregnant women: a clinical trial study

Authors: SholeShahgheibi, NasrinSoofizadeh, AidinMojtahedzadeh, MasomehRezaei, FaribaSeydoshohadaei, GhobadMoradi and NazliHamrah

Int J Med Res Health Sci.261-266 | pdf PDF Full Text

Preterm labor is defined as birth before 37th week of pregnancy. Despite of progressive improvement in
gynecological care, the prevalence of preterm labor is growing. The aim of this study was to investigate the effect of
α-Hydroxyprogestrone Caproate on prevention of preterm labor in high-risk pregnant women. This doubleblinded clinical trial study was conducted on 100 pregnant women who admitted to Besat hospital, Sananadj, Iran
during 2013-2014. Women were block randomized and divided in two intervention (n=50) and control (n=50)
groups. The intervention group was injected 250 mg 17
α-Hydroxyprogestrone Caproate intramuscularly during 24th
until 34th week on a weekly basis and placebo was given to control group. The results showed that 11 women (22%)
with preterm labor on less than 37 week and 39 (78%) on more than 37 week, however, in placebo group these
figures were 29 (58%) and 21 (42%), respectively. This finding showed that 17
α-Hydroxyprogestrone Caproate had
preventive effect on preterm labor in intervention group. The logistic regression also showed that there was a
significant difference between two intervention and control groups (p=0.001). It seems that 17
Hydroxyprogestrone Caproate had preventive effect on preterm labor

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