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The Comparison of the Influence of Thiopental and Propofol on Intraocular Pressure during Induction of Anesthesia in Intubated Patients under Cataracct Surgery

Authors: Reza Sahraei, Hossein Kargar Jahromi, Mohsen Adelpour, and Navid Kalani

Int J Med Res Health Sci.147-151 | pdf PDF Full Text

ABSTRACT
The prevention of the increase of intraocular pressure and the further decrease of it during eye surgery has an
impressive effect on the success of surgery. Some of the phases of the induction of anesthesia like laryngoscopy and
tracheal intubation result in the increase of intraocular pressure and its consequences are dangerous for
penetrating injuries of eyeball. The goal of this research is the comparison of the changes of intraocular pressure
during the induction of anesthesia in completely same conditions by using thiopental and propofol and also the
careful investigation of their influences on intraocular pressure in order to select the medicine that effectively
decrease the intraocular pressure and prevent the increase of it after laryngoscopy and tracheal intubation. In this
research, 88 patients were selected and they were randomly divided into 2 groups. In the beginning of the patients’
anesthesia, both groups were preoxygenated and they simultaneously receive initial dose of atracurium (0/5 mg/kg)
and then initial dose of fentanyl (1-2 μg/Kg). After prescription of fentanyl, the induction of anesthesia in the first
group was done withthiopental (4 mg/kg) and in the second group with propofol (2/5 mg/kg) and after that,
atracurium intubation (0/7 mg/kg) was prescribed. Intraocular pressure is measured in two phases before induction
of anesthesia (with tetracaine eyedrop) and 3 minutes after intubation (with schiotz tonometer and 3±0/75 degree of
accuracy) and by a person who is not aware of the kind of anesthesia. The patients are replicated in 2 experimental
and control groups in terms of age and gender. The results of independent t-test show that there is no significant
difference between 2 groups of thiopental and propofol in terms of systolic and diastolic blood pressure, heart beat
and eye pressure before the induction of anesthesia (p-value>0,05). The results of independent t-test show that there
is a significant difference between2 groups of thiopental and propofol in terms of diastolic blood pressure and eye
pressure after the induction of anesthesia (p-value<0,05). But there is no significant difference between 2 groups of
thiopental and propofol in terms of systolic blood pressure and heart beat after the induction of anesthesia (pvalue>
0,05). After the induction of anesthesia, the amount of systolic blood pressure and eye pressure was higher in
thiopental than propofol. Propofol results in the decrease of intraocular pressure more than thiopental and it
effectively prevents the increase of intraocular pressure after laryngoscopy and tracheal intubation
Key Words: intraocular pressure, induction of anesthesia, thiopental, propofol

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