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Serum zinc and selenium levels in breast cancer women: A report from Southeastern Iran

Authors: Seyed-Mehdi Hashemi, Masoud Sadeghi, Abdolbaset Vahedi Tabas, Salehoddin Bouya, Hosein Ali Danesh, Alireza Khazaei and Abolghasem Allahyari

Int J Med Res Health Sci.662-666 | pdf PDF Full Text

Zinc (Zn) and Selenium (Se) are trace minerals that have high anticancer and chemopreventive properties. The aim
of study was to evaluate of serum levels of both elements in women with breast cancer (BC) compared with control
group and the correlation of them with risk factors of BC. In a case-control study, 142 BC women and 158 healthy
controls, aged 19-88 years, were selected. Both groups, 3 months before entered in the study did not use any type of
supplement and there was no history of chronic kidney or liver disease or malabsorption disorders and body mass
index (BMI) was between 18.5 and 30 based on Quetelet index. Se by graphite furnace and Zn by flame were
atomized and the amount of each of the two elements was measured and recorded by the Absorption device. The
mean age of Zn was 689.57±146.13 mg/dL in the patient group and 874.85±150.53 mg/dL in the control group
(P<0.001). Also, the mean age of Se was 101.24±17.27 mg/dL in the patient group and 115.36±13.31 mg/dL in the
control group (P<0.001). There was a significant difference between Se level with and stage in patients that
therefore, Se level was lower in metastatic stage compared with another two stages (P=0.028). Decreasing of serum
levels of Se and Zn can be the risk factors for BC. It seems that the adding micro nutrients of zinc and selenium in
patients with low serum levels can reduce the risk of BC.

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