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Serum Level of Interleukin-18 to Interleukin-10 Ratio after Percutaneous Coronary Intervention: A New Predictor of In-Stent Restenosis

Authors: Nozar Givtaj, Hossein Ali Bassiri, Mohammad Mehdi Peighambari, Feridoun Noohi and Hooman Bakhshandeh

Int J Med Res Health Sci.12-16 | pdf PDF Full Text

Despite advanced techniques of stent placement which cause fewer traumas to the vessel walls; as well as
introduction of drug-eluting stents which result in the least induction of immune response, in-stent restenosis (ISR)
is still one of the common and severe complications after PCI and stent placement. Intimal hyperplasia following
immuno- inflammatory response of the arterial wall to balloon injury has been proposed as main mechanism of ISR.
In a prospective study, we assessed the predictive role of Interleukin (IL)-18 and tumor necrosis factor alpha (TNF-
α) as pro-inflammatory cytokines and IL-10 as anti-inflammatory cytokine and high sensitive C-reactive protein (hsCRP) for ISR. 128 patients (mean age=59±10.2, femal e/male: 41/87)who underwent percutaneous coronary
intervention (PCI) and stent implantation. Venous blood samples were obtained before and 24 hours after PCI. IL-
18, IL-10, TNF-
αand hs-CRP levels were determined. We followed the patients for24months and measured the
incidence of ISR via angiography. Results were compared between ISR and non-ISR patients. 20 patients (15.6%)
developed ISR. Serum level of IL-18, TNF-
α and hs-CRP have been increased in all patients 24 hours after PCI.
Serum level of IL-18 at 24-hours was not different between ISR and non-ISR patients (p=0.239), while serum level
of IL-10 was significantly higher in non-ISR group (p<0.001). IL-18/IL-10 was significantly higher in ISR patients
than in non-ISR patients (p<0.001). IL-18/IL-10 can be applied as predictive factors for ISR.

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