A special issue on Nursing: Current Scenario and Future Development - Articles are invited.

SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE AND LIPIDS IN YOUNG ADULTS WITH UNCOMPLICATED ESSENTIAL HYPERTENSION

Authors: Rajarajeswari D, Ramalingam, Sharmila T, Prasad Naidu M, Naidu JN

Int J Med Res Health Sci.2015;4(3):578-581 | pdf PDF Full Text

ABSTRACT

Introduction: Gamma-glutamyl transpeptidase initially used as an indicator of alcohol ingestion is now viewed as a sensitive marker of sub clinical inflammation. Recent clinical studies have shown its association with blood pressure and lipid profile.  As GGT degrades glutathione, an antioxidant GGT can be considered as a pro inflammatory marker playing a role in atherogenesis and hypertension. Materials and methods: 65  subjects with Essential hypertension  and 50 age and sex matched healthy controls  both male and female  between 18-50 years of age  were recruited from General Medicine  department  of Narayana Medical college and Hospital, Nellore, A.P. Serum  GGT  was   measured by calorimetric  kinetic assay. Fasting Serum Triglycerides, Total Cholesterol and HDL cholesterol by standard enzymatic procedures and LDL cholesterol by Friedwald equation. Results: GGT is significantly elevated in hypertensive subjects (Mean±SD 64.2±18.62IU/L) compared to controls (Mean±SD 26.20±8.91IU/L)  (P value <0.001). GGT is significantly correlated with systolic BP (r= 0.26 p<0.01) and diastolic BP(r= 0.28 p<0.01).  Conclusion: Our findings suggest that elevated GGT in young adults may contribute to their susceptibility to hypertension and provide an additional evidence of novel role of GGT in cardiovascular risk evaluation.

Keywords: Serum γ-glutamyl transpeptidase, Lipid profile, Young adults, Essential Hypertension.

How to Cite this Article

.

Pubmed Style:


Rajarajeswari D, Ramalingam, Sharmila T, Prasad Naidu M, Naidu JN . SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE AND LIPIDS IN YOUNG ADULTS WITH UNCOMPLICATED ESSENTIAL HYPERTENSION .Int J Med Res Health Sci. 2015;4(3):578-581.


Web Style:


Rajarajeswari D, Ramalingam, Sharmila T, Prasad Naidu M, Naidu JN . SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE AND LIPIDS IN YOUNG ADULTS WITH UNCOMPLICATED ESSENTIAL HYPERTENSION.


AMA (American Medical Association) Style:


Rajarajeswari D, Ramalingam, Sharmila T, Prasad Naidu M, Naidu JN . SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE AND LIPIDS IN YOUNG ADULTS WITH UNCOMPLICATED ESSENTIAL HYPERTENSION .Int J Med Res Health Sci. 2015;4(3):578-581.

International Journal of Medical Research & Health Sciences © 2012-16 [Last updated: July 2016] by AspiringDigital