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Serum anti mullerian hormone levels: A better hormonal marker of ovarian reserve

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Int J Med Res Health Sci. |

Authors: RadhaVembu, Sanjeeva Reddy Nellapalli, Anjalakshi Chandrashekar, Nalini Ganesan R
Int J Med Res Health Sci.2014;3(2):420-423 |  DOI: 10.5958/j.2319-5886.3.2.085

ABSTRACT

Aim: To determine whether Serum AMH is a better hormonal marker of Ovarian Reserve. Objectives: 1. To correlate AMH with FSH and maternal Age and whether AMH is a better predictor of ovarian response than FSH. Materials & Methods: A total of 246 women enrolled for IVF-ICSI fulfilling the selection criteria were recruited for the study at a tertiary ART centre. On day 3 of the cycle serum AMH, FSH were assayed along with LH, E2, TSH and Prolactin. Within 3 months they were subjected to IVF-ICSI. Serum AMH and FSH levels were compared with Age and Oocytes retrieved. Results:  All the 246 women enrolled were analysed. The mean age of the women was 30.7 ± 4.5, average number of oocytes retrieved was 11.8 ±7.1.  There was a negative correlation of AMH with age (r= -0.28) which is statistically significant where as FSH showed a positive correlation (r= -0.27). With regard to retrieval of mature oocytes, AMH showed a high positive correlation (r= 0.60) which is statistically significant (p <0.000) when compared to serum FSH (r = -0.26). Conclusion: AMH is a better hormonal marker of Ovarian Reserve and a better predictor of Oocytes retrieved than serum FSH levels.

Key words: AMH, Ovarian reserve, ovarian response

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