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Relationship between selenium and prostate cancer risk; systematic review and meta-analysis and meta-regression

Authors: Yadolah Fakhri, Parviz Kokhaei, Mahboobeh Moradi, Maryam Dadar, Nazak Amanidaz, Yahya Zandsalimi, Bigard Moradi, Leila Rasouli Amirhajeloo and Hassan Keramati

Int J Med Res Health Sci.44-55 | pdf PDF Full Text

Prostate cancer is one of the five most common cancers in men. It is suspected that selenium protect or exacerbate
the risk of prostate cancer. The aim of this study was to determine the association between prostate cancer risk and
selenium in the serum, toenail and supplements. So it was tried to do a systematic review and meta-analysis and
meta-regression of 22 studies (5 toenail studies, 14 serum studies and 3 supplements studies) in order to obtain
detailed results of these studies’ data. Meta-regression results showed that location of study (p value <0.001), type
of study (p value = 0.04) and age (p value =0.008) have significant effects on heterogeneity. There was no
publication bias in studies (Begger’s test: z-value = 1.98; P value=0.067). In general, unlike selenium supplements
[OR=0.86 (CI: 0.7-1.06, P value=0.15], selenium increase in serum [OR=0.76 (0.59-0.99, P value=0.04] and
toenail [OR=0.58 (0.4-0.86, P value=0.01] significantly decreased the risk of prostate cancer by %24 and 42 %. In
general, the odds ratio between prostate cancer caused by selenium in the random effect model OR: 0.71 (CI: 0.59-
0.86%, P value <0.001) and heterogeneity was moderate (I2 = 70.6%, P value <0.001). The results of this study
supported the lowering effect of selenium in serum and toenail on the risk of prostate cancer.
Key words: Selenium, Prostate Cancer, Serum, Toenail, Supplements, Meta-analysis and Meta-regression

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